Access to Cyclopropyl-Fused Azacycles via a Palladium-Catalyzed Direct Alkenylation Strategy

Palladium(II)-catalyzed direct alkenylation of dihydropyranones.

A palladium(II)-catalyzed direct alkenylation reaction of dihydropyranones was developed. Various substituted dihydropyranones could afford the desired products in reasonable yields. And different acrylates were found to be good coupling partners in this coupling reaction. A Pd(0)/Pd(II) catalytic pathway was proposed to be involved in this coupling reaction.

Palladium-catalyzed direct C-3 oxidative alkenylation of phosphachromones.

A method for the synthesis of C-3 alkenylated phosphachromones was developed using a direct intermolecular C-3 alkenylation with activated and non-activated alkenes through C-H activation under aerobic conditions.

Palladium-Catalyzed Alkenylation by the Negishi Coupling

Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides.

The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.

Synthesis of 2-Cyclopentenone Derivatives via Palladium-Catalyzed Intramolecular Carbonyl α-Alkenylation.

2-Cyclopentenone derivatives have been efficiently synthesized from 5-bromo-5-hexen-2-ones via palladium-catalyzed intramolecular carbonyl α-alkenylation followed by double-bond migration under mild reaction conditions.